A systems biology pipeline identifies new immune and disease related molecular signatures and networks in human cells during microgravity exposure.

ABSTRACT: Microgravity is a prominent health hazard for astronauts, yet we understand little about its effect at the molecular systems level. In this study, we have integrated a set of systems-biology tools and databases and have analysed more than 8000 molecular pathways on published global gene expression datasets of human cells in microgravity. Hundreds of new pathways have been identified with statistical confidence for each dataset and despite the difference in cell types and experiments, around 100 of the new pathways are appeared common across the datasets. They are related to reduced inflammation, autoimmunity, diabetes and asthma. We have identified downregulation of NfκB pathway via Notch1 signalling as new pathway for reduced immunity in microgravity. Induction of few cancer types includi

SUBMITTER: Mukhopadhyay S 

PROVIDER: S-EPMC4868995 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature