Mediator subunit Med12 contributes to the maintenance of neural stem cell identity.

ABSTRACT:

Background

The RNA polymerase II transcriptional Mediator subunit Med12 is broadly implicated in vertebrate brain development, and genetic variation in human MED12 is associated with X-linked intellectual disability and neuropsychiatric disorders. Although prior studies have begun to elaborate the functional contribution of Med12 within key neurodevelopmental pathways, a more complete description of Med12 function in the developing nervous system, including the specific biological networks and cellular processes under its regulatory influence, remains to be established. Herein, we sought to clarify the global contribution of Med12 to neural stem cell (NSC) biology through unbiased transcriptome profiling of mouse embryonic stem (ES) cell-derived NSCs following RNAi-mediated Med12 d

SUBMITTER: Kim NH 

PROVIDER: S-EPMC4869265 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature