Putative virulence factors of Corynebacterium pseudotuberculosis FRC41: vaccine potential and protein expression.

ABSTRACT:

Background

Corynebacterium pseudotuberculosis, a facultative intracellular bacterial pathogen, is the etiological agent of caseous lymphadenitis (CLA), an infectious disease that affects sheep and goats and it is responsible for significant economic losses. The disease is characterized mainly by bacteria-induced caseous necrosis in lymphatic glands. New vaccines are needed for reliable control and management of CLA. Thus, the putative virulence factors SpaC, SodC, NanH, and PknG from C. pseudotuberculosis FRC41 may represent new target proteins for vaccine development and pathogenicity studies.

Results

SpaC, PknG and NanH presented better vaccine potential than SodC after in silico analyses. A total of 136 B and T cell epitopes were predicted from the four putative virulence

SUBMITTER: Santana-Jorge KT 

PROVIDER: S-EPMC4869379 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature