Geographic variation in human papillomavirus-related oropharyngeal cancer: Data from 4 multinational randomized trials.

ABSTRACT:

Background

There are variations in the proportions of head and neck cancers caused by the human papillomavirus (HPV) between countries and regions. It is unclear if these are true variations or due to different study designs and assays.

Methods

We tested formalin-fixed paraffin-embedded diagnostic biopsies for p16 immunohistochemistry and HPV-DNA (by polymerase chain reaction [PCR] and in situ hybridization [ISH]) using validated protocols on samples from 801 patients with head and neck cancer recruited prospectively between 2006 and 2011 in 4 randomized controlled trials (RCTs).

Results

Twenty-one percent of patients (170 of 801) showed both HPV-DNA and p16-positivity, detected almost exclusively in oropharyngeal cancer (55%; 15 of 302); and only 1% of the patients (

SUBMITTER: Mehanna H 

PROVIDER: S-EPMC4869674 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature