Bile duct-ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences.

ABSTRACT:

Background & aims

Patients with decompensated cirrhosis are susceptible to infection. Innate immune dysfunction and development of organ failure are considered to underlie this. A rodent model of liver disease sharing these phenotypic features would assist in vivo study of underlying mechanisms and testing of therapeutics. We evaluated three models to identify which demonstrated the greatest clinical and immunological phenotypic similarity to patients with acutely decompensated (AD) cirrhosis.

Methods

We selected Bile Duct Ligation (BDL) rats at 4 weeks, BDL mice at 14 days and Carbon tetrachloride (CCl4 ) mice at 10 weeks (with studies performed 7 days after final CCl4 infection). We examined organ dysfunction, inflammatory response to carrageenan-in-paw, plasma eicosanoid

SUBMITTER: O'Brien A 

PROVIDER: S-EPMC4869675 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature