Heterometallic titanium-gold complexes inhibit renal cancer cells in vitro and in vivo.

ABSTRACT: Following recent work on heterometallic titanocene-gold complexes as potential chemotherapeutics for renal cancer, we report here on the synthesis, characterization and stability studies of new titanocene complexes containing a methyl group and a carboxylate ligand (mba = S-C₆H₄-COO^-) bound to gold(I)-phosphane fragments through a thiolate group ([(η-C₅H₅)₂TiMe(μ-mba)Au(PR₃)]. The compounds are more stable in physiological media than those previously reported and are highly cytotoxic against human cancer renal cell lines. We describe here preliminary mechanistic data involving studies on the interaction of selected compounds with plasmid (pBR322) DNA used as a model nucleic acid, and with selected pr

SUBMITTER: Fernandez-Gallardo J 

PROVIDER: S-EPMC4869729 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature