Ketamine Alters Outcome-Related Local Field Potentials in Monkey Prefrontal Cortex.

ABSTRACT: A subanesthetic dose of the noncompetitive N-methyl-d-aspartate receptor antagonist ketamine is known to induce a schizophrenia-like phenotype in humans and nonhuman primates alike. The transient behavioral changes mimic the positive, negative, and cognitive symptoms of the disease but the neural mechanisms behind these changes are poorly understood. A growing body of evidence indicates that the cognitive control processes associated with prefrontal cortex (PFC) regions relies on groups of neurons synchronizing at narrow-band frequencies measurable in the local field potential (LFP). Here, we recorded LFPs from the caudo-lateral PFC of 2 macaque monkeys performing an antisaccade task, which requires the suppression of an automatic saccade toward a stimulus and the initiation of a goal-dire

SUBMITTER: Skoblenick KJ 

PROVIDER: S-EPMC4869811 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature