Effects of Hormone Therapy on Intraocular Pressure: The Women's Health Initiative-Sight Exam Study.

ABSTRACT:

Purpose

Previous studies suggest that hormone therapy favorably affects intraocular pressure (IOP). Here, we examined the association between hormone therapy use and IOP in the context of a large randomized trial.

Design

Secondary data analysis from a randomized controlled trial.

Methods

We used data from the Women's Health Initiative-Sight Exam (WHISE). Women with prior hysterectomy received oral conjugated equine estrogen (0.625 mg/day) or placebo. Women with a uterus received estrogen plus progestin (medroxyprogesterone acetate 2.5 mg/day) or placebo. IOP was measured 5 years after randomization. Adjusted linear regression models were used to assess the association between hormone therapy and IOP.

Results

The WHISE included 1668 women in the estrogen-alone t

SUBMITTER: Vajaranant TS 

PROVIDER: S-EPMC4870123 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature