The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII.

ABSTRACT:

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Essentials How the Alzheimer's disease (AD) peptide β-amyloid (Aβ) disrupts neuronal function in the disease is unclear. Factor (F) XII initiates blood clotting via FXI, and thrombosis has been implicated in AD. Aβ triggers FXII-dependent FXI and thrombin activation, evidence of which is seen in AD plasma. Aβ-triggered clotting could contribute to neuronal dysfunction in AD and be a novel therapeutic target.

Summary

Background β-Amyloid (Aβ) is a key pathologic element in Alzheimer's disease (AD), but the mechanisms by which it disrupts neuronal function in vivo are not completely understood. AD is characterized by a prothrombotic state, which could contribute to neuronal dysfunction by affecting cerebral blood flow and inducing inflammation. The plasma protein fa

SUBMITTER: Zamolodchikov D 

PROVIDER: S-EPMC4870142 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature