Insulin/IGF and sex hormone axes in human endometrium and associations with endometrial cancer risk factors.

ABSTRACT:

Purpose

Experimental and observational data link insulin, insulin-like growth factor (IGF), and estrogens to endometrial tumorigenesis. However, there are limited data regarding insulin/IGF and sex hormone axes protein and gene expression in normal endometrial tissues, and very few studies have examined the impact of endometrial cancer risk factors on endometrial tissue biology.

Methods

We evaluated endometrial tissues from 77 premenopausal and 30 postmenopausal women who underwent hysterectomy for benign indications and had provided epidemiological data. Endometrial tissue mRNA and protein levels were measured using quantitative real-time PCR and immunohistochemistry, respectively.

Results

In postmenopausal women, we observed higher levels of phosphorylated IGF-I/ins

SUBMITTER: Merritt MA 

PROVIDER: S-EPMC4870288 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature