Approximating the stabilization of cellular metabolism by compartmentalization.

ABSTRACT: Biochemical regulation in compartmentalized metabolic networks is highly complex and non-intuitive. This is particularly true for cells of higher plants showing one of the most compartmentalized cellular structures across all kingdoms of life. The interpretation and testable hypothesis generation from experimental data on such complex systems is a challenging step in biological research and biotechnological applications. While it is known that subcellular compartments provide defined reaction spaces within a cell allowing for the tight coordination of complex biochemical reaction sequences, its role in the coordination of metabolic signals during metabolic reprogramming due to environmental fluctuations is less clear. In the present study, we numerically analysed the effects of environment

SUBMITTER: Furtauer L 

PROVIDER: S-EPMC4870308 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature