Increase in Growth Cone Size Correlates with Decrease in Neurite Growth Rate.

ABSTRACT: Several important discoveries in growth cone cell biology were made possible by the use of growth cones derived from cultured Aplysia bag cell neurons, including the characterization of the organization and dynamics of the cytoskeleton. The majority of these Aplysia studies focused on large growth cones induced by poly-L-lysine substrates at early stages in cell culture. Under these conditions, the growth cones are in a steady state with very little net advancement. Here, we offer a comprehensive cellular analysis of the motile behavior of Aplysia growth cones in culture beyond this pausing state. We found that average growth cone size decreased with cell culture time whereas average growth rate increased. This inverse correlation of growth rate and growth cone size was due to the occurren

SUBMITTER: Ren Y 

PROVIDER: S-EPMC4870373 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature