Heme pathway evolution in kinetoplastid protists.

ABSTRACT:

Background

Kinetoplastea is a diverse protist lineage composed of several of the most successful parasites on Earth, organisms whose metabolisms have coevolved with those of the organisms they infect. Parasitic kinetoplastids have emerged from free-living, non-pathogenic ancestors on multiple occasions during the evolutionary history of the group. Interestingly, in both parasitic and free-living kinetoplastids, the heme pathway-a core metabolic pathway in a wide range of organisms-is incomplete or entirely absent. Indeed, Kinetoplastea investigated thus far seem to bypass the need for heme biosynthesis by acquiring heme or intermediate metabolites directly from their environment.

Results

Here we report the existence of a near-complete heme biosynthetic pathway in Perkinsela

SUBMITTER: Cenci U 

PROVIDER: S-EPMC4870792 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature