Growth arrest specific gene 7 is associated with schizophrenia and regulates neuronal migration and morphogenesis.

ABSTRACT:

Background

Schizophrenia is a highly heritable chronic mental disorder with significant abnormalities in brain function. The neurodevelopmental hypothesis proposes that schizophrenia originates in the prenatal period due to impairments in neuronal developmental processes such as migration and arborization, leading to abnormal brain maturation. Previous studies have identified multiple promising candidate genes that drive functions in neurodevelopment and are associated with schizophrenia. However, the molecular mechanisms of how they exert effects on the pathophysiology of schizophrenia remain largely unknown.

Results

In our research, we identified growth arrest specific gene 7 (GAS7) as a schizophrenia risk gene in two independent Han Chinese populations using a two-stage a

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC4870797 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature