Cell-Type Dependent Effect of Surface-Patterned Microdot Arrays on Neuronal Growth.

ABSTRACT: Surface micropatterns have been widely used as chemical cues to control the microenvironment of cultured neurons, particularly for neurobiological assays and neurochip designs. However, the cell-type dependency on the interactions between neurons and underlying micropatterns has been rarely investigated despite the inherent differences in the morphology of neuronal types. In this study, we used surface-printed microdot arrays to investigate the effect of the same micropatterns on the growth of mouse spinal interneuron, mouse hippocampal neurons, and rat hippocampal neurons. While mouse hippocampal neurons showed no significantly different growth on control and patterned substrates, we found the microdot arrays had different effects on early neuronal growth depending on the cell type; spina

SUBMITTER: Jang MJ 

PROVIDER: S-EPMC4870857 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature