Genome-wide prediction of childhood asthma and related phenotypes in a longitudinal birth cohort.

ABSTRACT:

Background

Childhood wheezing and asthma vary greatly in clinical presentation and time course. The extent to which phenotypic variation reflects heterogeneity in disease pathways is unclear.

Objective

We sought to assess the extent to which single nucleotide polymorphisms (SNPs) associated with childhood asthma in a genome-wide association study are predictive of asthma-related phenotypes.

Methods

In 8365 children from a population-based birth cohort, the Avon Longitudinal Study of Parents and Children, allelic scores were derived based on between 10 and 215,443 SNPs ranked according to the inverse of the P value for their association with physician-diagnosed asthma in an independent genome-wide association study (6176 cases and 7111 control subjects). We assessed th

SUBMITTER: Spycher BD 

PROVIDER: S-EPMC4871225 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature