Tetraspanin CD151 Is a Negative Regulator of FcεRI-Mediated Mast Cell Activation.

ABSTRACT: Mast cells are critical in the pathogenesis of allergic disease due to the release of preformed and newly synthesized mediators, yet the mechanisms controlling mast cell activation are not well understood. Members of the tetraspanin family are recently emerging as modulators of FcεRI-mediated mast cell activation; however, mechanistic understanding of their function is currently lacking. The tetraspanin CD151 is a poorly understood member of this family and is specifically induced on mouse and human mast cells upon FcεRI aggregation but its functional effects are unknown. In this study, we show that CD151 deficiency significantly exacerbates the IgE-mediated late phase inflammation in a murine model of passive cutaneous anaphylaxis. Ex vivo, FcεRI stimulation of bone marrow-derived mast ce

SUBMITTER: Abdala-Valencia H 

PROVIDER: S-EPMC4871253 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature