Discovery of the gray phenotype and white-gray-opaque tristable phenotypic transitions in Candida dubliniensis.

ABSTRACT: Candida dubliniensis is closely related to Candida albicans, a major causative agent of candidiasis, and is primarily associated with oral colonization and infection in human immunodeficiency virus (HIV)-positive patients. Despite the high similarity of genomic and phenotypic features between the 2 species, C. dubliniensis is much less virulent and less prevalent than C. albicans. The ability to change morphological phenotypes is a striking feature of Candida species and is linked to virulence. In this study, we report a novel phenotype, the gray phenotype, in C. dubliniensis. Together with the previously reported white and opaque cell types, the gray phenotype forms a tristable phenotypic switching system in C. dubliniensis that is similar to the white-gray-opaque tristable switching syst

SUBMITTER: Yue H 

PROVIDER: S-EPMC4871672 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature