Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development.

ABSTRACT: Formation of the coronary vasculature is a complex and precisely coordinated morphogenetic process that begins with the formation of epicardium. The epicardium gives rise to many components of the coronary vasculature, including fibroblasts, smooth muscle cells, and endothelium. Hippo signaling components have been implicated in cardiac development and regeneration. However, a role of Hippo signaling in the epicardium has not been explored. Employing a combination of genetic and pharmacological approaches, we demonstrate that inhibition of Hippo signaling mediators Yap and Taz leads to impaired epicardial epithelial-to-mesenchymal transition (EMT) and a reduction in epicardial cell proliferation and differentiation into coronary endothelial cells. We provide evidence that Yap and Taz contr

SUBMITTER: Singh A 

PROVIDER: S-EPMC4871746 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature