Dataset Information
The Taf14 YEATS domain is a reader of histone crotonylation.
Ontology highlight
ABSTRACT:
SUBMITTER: Andrews FH
PROVIDER: S-EPMC4871749 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
The Taf14 YEATS domain is a reader of histone crotonylation.
Nature chemical biology 20160418 6
The discovery of new histone modifications is unfolding at startling rates; however, the identification of effectors capable of interpreting these modifications has lagged behind. Here we report the YEATS domain as an effective reader of histone lysine crotonylation, an epigenetic signature associated with active transcription. We show that the Taf14 YEATS domain engages crotonyllysine via a unique π-π-π-stacking mechanism and that other YEATS domains have crotonyllysine-binding activity. ...[more]
