Uncertainties in estimating heart doses from 2D-tangential breast cancer radiotherapy.

ABSTRACT:

Background and purpose

We evaluated the accuracy of three methods of estimating radiation dose to the heart from two-dimensional tangential radiotherapy for breast cancer, as used in Denmark during 1982-2002.

Material and methods

Three tangential radiotherapy regimens were reconstructed using CT-based planning scans for 40 patients with left-sided and 10 with right-sided breast cancer. Setup errors and organ motion were simulated using estimated uncertainties. For left-sided patients, mean heart dose was related to maximum heart distance in the medial field.

Results

For left-sided breast cancer, mean heart dose estimated from individual CT-scans varied from <1Gy to >8Gy, and maximum dose from 5 to 50Gy for all three regimens, so that estimates based only on regimen ha

SUBMITTER: Lorenzen EL 

PROVIDER: S-EPMC4871929 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature