Postprandial Levels of Branch Chained and Aromatic Amino Acids Associate with Fasting Glycaemia.

ABSTRACT: High fasting plasma concentrations of isoleucine, phenylalanine, and tyrosine have been associated with increased risk of hyperglycaemia and incidence of type 2 diabetes. Whether these associations are diet or metabolism driven is unknown. We examined how the dietary protein source affects the postprandial circulating profile of these three diabetes associated amino acids (DMAAs) and tested whether the postprandial DMAA profiles are associated with fasting glycaemia. We used a crossover design with twenty-one healthy individuals and four different isocaloric test meals, containing proteins from different dietary sources (dairy, fish, meat, and plants). Analysis of the postprandial DMAAs concentrations was performed using targeted mass spectrometry. A DMAA score was defined as the sum of al

SUBMITTER: Ottosson F 

PROVIDER: S-EPMC4871975 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature