Ontology highlight
ABSTRACT:
SUBMITTER: HafezQorani S
PROVIDER: S-EPMC4872080 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
HafezQorani Saber S Lafzi Atefeh A de Bruin Ruben G RG van Zonneveld Anton Jan AJ van der Veer Eric P EP Son Yeşim Aydın YA Kazan Hilal H
Nucleic acids research 20160202 9
Recent studies show that RNA-binding proteins (RBPs) and microRNAs (miRNAs) function in coordination with each other to control post-transcriptional regulation (PTR). Despite this, the majority of research to date has focused on the regulatory effect of individual RBPs or miRNAs. Here, we mapped both RBP and miRNA binding sites on human 3'UTRs and utilized this collection to better understand PTR. We show that the transcripts that lack competition for HuR binding are destabilized more after HuR ...[more]