Ontology highlight
ABSTRACT:
SUBMITTER: Harwig A
PROVIDER: S-EPMC4872094 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Harwig Alex A Jongejan Aldo A van Kampen Antoine H C AH Berkhout Ben B Das Atze T AT
Nucleic acids research 20160316 9
Evidence is accumulating that retroviruses can produce microRNAs (miRNAs). To prevent cleavage of their RNA genome, retroviruses have to use an alternative RNA source as miRNA precursor. The transacting responsive (TAR) hairpin structure in HIV-1 RNA has been suggested as source for miRNAs, but how these small RNAs are produced without impeding virus replication remained unclear. We used deep sequencing analysis of AGO2-bound HIV-1 RNAs to demonstrate that the 3' side of the TAR hairpin is proce ...[more]