Gene expression changes in the retina following subretinal injection of human neural progenitor cells into a rodent model for retinal degeneration.

ABSTRACT:

Purpose

Retinal degenerative diseases (RDDs) affect millions of people and are the leading cause of vision loss. Although treatment options for RDDs are limited, stem and progenitor cell-based therapies have great potential to halt or slow the progression of vision loss. Our previous studies have shown that a single subretinal injection of human forebrain derived neural progenitor cells (hNPCs) into the Royal College of Surgeons (RCS) retinal degenerate rat offers long-term preservation of photoreceptors and visual function. Furthermore, neural progenitor cells are currently in clinical trials for treating age-related macular degeneration; however, the molecular mechanisms of stem cell-based therapies are largely unknown. This is the first study to analyze gene expression changes i

SUBMITTER: Jones MK 

PROVIDER: S-EPMC4872275 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature