The algorithm for Alzheimer risk assessment based on APOE promoter polymorphisms.

ABSTRACT:

Background

Over the past two decades, the APOE gene and its polymorphisms have been among the most studied risk factors of Alzheimer disease (AD) development; yet, there are discrepancies between various studies regarding their impact. For this reason, the evaluation of the APOE genotype has not been included in the current European Federation of Neurological Societies guidelines for AD diagnosis and management. This aim of this study was to add to this discussion by assessing the possible influence of multiple polymorphisms in the promoter region of the APOE gene and genotypes of its allele E on the risk for dementia.

Methods

We performed a comprehensive analysis of APOE gene polymorphisms, assessed the detected genotypes and correlated molecular findings with serum apolipo

SUBMITTER: Limon-Sztencel A 

PROVIDER: S-EPMC4872351 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature