Neuroplasticity in response to cognitive behavior therapy for social anxiety disorder.

ABSTRACT: Patients with anxiety disorders exhibit excessive neural reactivity in the amygdala, which can be normalized by effective treatment like cognitive behavior therapy (CBT). Mechanisms underlying the brain's adaptation to anxiolytic treatments are likely related both to structural plasticity and functional response alterations, but multimodal neuroimaging studies addressing structure-function interactions are currently missing. Here, we examined treatment-related changes in brain structure (gray matter (GM) volume) and function (blood-oxygen level dependent, BOLD response to self-referential criticism) in 26 participants with social anxiety disorder randomly assigned either to CBT or an attention bias modification control treatment. Also, 26 matched healthy controls were included. Significant

SUBMITTER: Mansson KN 

PROVIDER: S-EPMC4872422 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature