Infrequent TRIB3 coding variants and coronary artery disease in type 2 diabetes.

ABSTRACT:

Objective

Genes that modulate insulin sensitivity may also be involved in shaping the risk of coronary artery disease (CAD). The relatively common TRIB3 Q84R polymorphism (rs2295490) has been associated with abnormal insulin signaling, endothelial dysfunction, insulin resistance, and pro-atherogenic phenotypes. The aim of our study was to investigate the association between low-frequency TRIB3 coding variants and CAD in patients with type 2 diabetes (T2D).

Methods

Three case-control studies for CAD from Italy and US were analyzed, for a total of 1565 individuals, all with type 2 diabetes. Infrequent variants were identified by re-sequencing TRIB3 exons in 140 "extreme cases" and 140 "super-controls" and then genotyped in all study subjects.

Results

TRIB3 infrequent va

SUBMITTER: Prudente S 

PROVIDER: S-EPMC4872508 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature