Association between Beckwith-Wiedemann syndrome and assisted reproductive technology: a case series of 19 patients.

ABSTRACT:

Objective

An association between assisted reproductive technique (ART) and specific imprinting mutations, such as Beckwith-Wiedemann syndrome (BWS), has recently been documented. Based on experiments in farm animals that demonstrated an association between alterations in culture media during ART and large offspring syndrome, we hypothesized that the culture media could be implicated as a common factor among the children with BWS conceived after ART.

Design

Retrospective case series.

Setting

Registry from Academic Medical Center.

Patient(s)

Nineteen children born after ART were identified within the registry.

Main outcome measure(s)

Demographics of patients, type of ART, culture media, IVF parameters.

Result(s)

Twelve of the 19 medical records from

SUBMITTER: Chang AS 

PROVIDER: S-EPMC4872595 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature