Smooth Muscle Enriched Long Noncoding RNA (SMILR) Regulates Cell Proliferation.

ABSTRACT:

Background

Phenotypic switching of vascular smooth muscle cells from a contractile to a synthetic state is implicated in diverse vascular pathologies, including atherogenesis, plaque stabilization, and neointimal hyperplasia. However, very little is known about the role of long noncoding RNA (lncRNA) during this process. Here, we investigated a role for lncRNAs in vascular smooth muscle cell biology and pathology.

Methods and results

Using RNA sequencing, we identified >300 lncRNAs whose expression was altered in human saphenous vein vascular smooth muscle cells following stimulation with interleukin-1α and platelet-derived growth factor. We focused on a novel lncRNA (Ensembl: RP11-94A24.1), which we termed smooth muscle-induced lncRNA enhances replication (SMILR). Following

SUBMITTER: Ballantyne MD 

PROVIDER: S-EPMC4872641 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature