Pretreatment with Antioxidants Augments the Acute Arterial Vasoconstriction Caused by Diesel Exhaust Inhalation.

ABSTRACT:

Rationale

Diesel exhaust inhalation, which is the model traffic-related air pollutant exposure, is associated with vascular dysfunction.

Objectives

To determine whether healthy subjects exposed to diesel exhaust exhibit acute vasoconstriction and whether this effect could be modified by the use of antioxidants or by common variants in the angiotensin II type 1 receptor (AGTR1) and other candidate genes.

Methods

In a genotype-stratified, double-blind, four-way crossover study, 21 healthy adult subjects were exposed at rest in a randomized, balanced order to diesel exhaust (200 μg/m(3) particulate matter with an aerodynamic diameter ≤ 2.5 μm [PM2.5]) and filtered air, and to pretreatment with antioxidants (N-acetylcysteine and ascorbate) and placebo. Before and after ea

SUBMITTER: Sack CS 

PROVIDER: S-EPMC4872652 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature