Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

ABSTRACT:

Aims

Extracellular matrix remodelling has been implicated in a number of vascular conditions, including venous hypertension and varicose veins. However, to date, no systematic analysis of matrix remodelling in human veins has been performed.

Methods and results

To understand the consequences of venous hypertension, normal and varicose veins were evaluated using proteomics approaches targeting the extracellular matrix. Varicose saphenous veins removed during phlebectomy and normal saphenous veins obtained during coronary artery bypass surgery were collected for proteomics analysis. Extracellular matrix proteins were enriched from venous tissues. The proteomics analysis revealed the presence of >150 extracellular matrix proteins, of which 48 had not been previously detected in

SUBMITTER: Barallobre-Barreiro J 

PROVIDER: S-EPMC4872879 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature