An Integrated Data Driven Approach to Drug Repositioning Using Gene-Disease Associations.

ABSTRACT: Drug development is both increasing in cost whilst decreasing in productivity. There is a general acceptance that the current paradigm of R&D needs to change. One alternative approach is drug repositioning. With target-based approaches utilised heavily in the field of drug discovery, it becomes increasingly necessary to have a systematic method to rank gene-disease associations. Although methods already exist to collect, integrate and score these associations, they are often not a reliable reflection of expert knowledge. Furthermore, the amount of data available in all areas covered by bioinformatics is increasing dramatically year on year. It thus makes sense to move away from more generalised hypothesis driven approaches to research to one that allows data to generate their own hypothesi

SUBMITTER: Mullen J 

PROVIDER: S-EPMC4873016 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature