Increased Cord Blood Betatrophin Levels in the Offspring of Mothers with Gestational Diabetes.

ABSTRACT:

Aim

Exposing a fetus to hyperglycemia can increase the risk for later-life metabolic disorders. Betatrophin has been proposed as a key regulator of pancreatic beta cell proliferation and lipid regulation. Highly responsive to nutritional signals, serum betatrophin concentrations have been found to be altered by various physiological and pathological conditions. We hypothesized that betatrophin levels are increased in the cord blood in offspring exposed to intrauterine hyperglycemia.

Methods

This was a cross-sectional study including 54 mothers who underwent uncomplicated Cesarean delivery in a university hospital. Maternal gestational glucose concentration was determined at 24-48 weeks gestation after a 75-g OGTT. Cord blood and placental tissue was collected immediately pos

SUBMITTER: Xie X 

PROVIDER: S-EPMC4873017 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature