An FTO Gene Variant Moderates the Association between Parental Restriction and Child BMI.

ABSTRACT:

Objective

This study aimed to explore whether a common variant in the FTO gene moderates the relationship between parental restriction and child BMI.

Methods

This study reports on baseline data from 178 parent-child (ages 9-10 years) dyads. Parents completed the Child Feeding Questionnaire and reported on socio-demographic characteristics. Each child's height, weight and FTO rs9939609 genotype was assessed. Ordinary least squares regression was used to fit the child's BMI-percentile on parental restriction and the child's FTO genotype, adjusted for covariates. A likelihood ratio test was used to compare a model with and without a multiplicative interaction term between restriction and genotype.

Results

Most participants (93.3%) were white, non-Hispanic. Twenty-three p

SUBMITTER: Tovar A 

PROVIDER: S-EPMC4873182 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature