Deletion of Interstitial Genes between TMPRSS2 and ERG Promotes Prostate Cancer Progression.

ABSTRACT: TMPRSS2-ERG gene fusions that occur frequently in human prostate cancers can be generated either through insertional chromosomal rearrangement or by intrachromosomal deletion. Genetically, a key difference between these two mechanisms is that the latter results in deletion of a ∼3-Mb interstitial region containing genes with unexplored roles in prostate cancer. In this study, we characterized two mouse models recapitulating TMPRSS2-ERG insertion or deletion events in the background of prostate-specific PTEN deficiency. We found that only the mice that lacked the interstitial region developed prostate adenocarcinomas marked by poor differentiation and epithelial-to-mesenchymal transition. Mechanistic investigations identified several interstitial genes, including Ets2 and Bace2, whose reduc

SUBMITTER: Linn DE 

PROVIDER: S-EPMC4873435 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature