TCR Sequencing Can Identify and Track Glioma-Infiltrating T Cells after DC Vaccination.

ABSTRACT: Although immunotherapeutic strategies are emerging as adjunctive treatments for cancer, sensitive methods of monitoring the immune response after treatment remain to be established. We used a novel next-generation sequencing approach to determine whether quantitative assessments of tumor-infiltrating lymphocyte (TIL) content and the degree of overlap of T-cell receptor (TCR) sequences in brain tumors and peripheral blood were predictors of immune response and overall survival in glioblastoma patients treated with autologous tumor lysate-pulsed dendritic cell immunotherapy. A statistically significant correlation was found between a higher estimated TIL content and increased time to progression and overall survival. In addition, we were able to assess the proportion of shared TCR sequences

SUBMITTER: Hsu M 

PROVIDER: S-EPMC4873445 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature