Pathway Analysis of Genome-wide Association Study in Childhood Leukemia among Hispanics.

ABSTRACT:

Background

The incidence of acute lymphoblastic leukemia (ALL) is nearly 20% higher among Hispanics than non-Hispanic Whites. Previous studies have shown evidence for association between risk of ALL and variation within IKZF1, ARID5B, CEBPE, CDKN2A, GATA3, and BM1-PIP4K2A genes. However, variants identified only account for <10% of the genetic risk of ALL.

Methods

We applied pathway-based analyses to genome-wide association study (GWAS) data from the California Childhood Leukemia Study to determine whether different biologic pathways were overrepresented in childhood ALL and major ALL subtypes. Furthermore, we applied causal inference and data reduction methods to prioritize candidate genes within each identified overrepresented pathway, while accounting for correlation amon

SUBMITTER: Hsu LI 

PROVIDER: S-EPMC4873450 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature