Early prediction of pathological response in locally advanced rectal cancer based on sequential 18F-FDG PET.

ABSTRACT:

Background

The objectives of this study were to investigate the predictive value of sequential (18)F-FDG PET scans for pathological tumor response grade (TRG) after preoperative chemoradiotherapy (PCRT) in locally advanced rectal cancer (LARC) and the impact of partial volume effects correction (PVC).

Methods

Twenty-eight LARC patients were included. Responders and non-responders status were determined in histopathology. PET indices [SUV max and mean, volume and total lesion glycolysis (TLG)] at baseline and their evolution after one and two weeks of PCRT were extracted by delineation of the PET images, with or without PVC. Their predictive value was investigated using Mann-Whitney-U tests and ROC analysis.

Results

Within baseline parameters, only SUVmean was correlat

SUBMITTER: Hatt M 

PROVIDER: S-EPMC4873546 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature