Changes in posterior scleral collagen microstructure in canine eyes with an ADAMTS10 mutation.

ABSTRACT:

Purpose

We aimed to characterize alterations in the posterior scleral collagen microstructure before detectable disease onset in a canine model of open-angle glaucoma caused by an ADAMTS10 mutation.

Methods

Collagen orientation, anisotropy degree (proportion of preferentially aligned collagen), and relative density were measured at 0.4 mm spatial resolution using synchrotron wide-angle X-ray scattering. For statistical evaluation of structure parameters, regional averages of the peripapillary and mid-posterior sclera were compared between ADAMTS10 mutant (affected) dogs (n = 3) and age-matched (carrier) controls (n = 3).

Results

No marked differences in the general pattern of preferential collagen fibril orientation were noted between the control and affected dogs. Th

SUBMITTER: Boote C 

PROVIDER: S-EPMC4873561 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature