Cortical folding of the preterm brain: a longitudinal analysis of extremely preterm born neonates using spectral matching.

ABSTRACT:

Introduction

Infants born extremely preterm (<28 weeks of gestation) are at risk of significant neurodevelopmental sequelae. In these infants birth coincides with a period of rapid brain growth and development, when the brain is also vulnerable to a range of insults. Mapping these changes is crucial for identifying potential biomarkers to predict early impairment.

Methods

In this study we use surface-based spectral matching techniques to find an intrasubject longitudinal surface correspondence between the white-grey matter boundary at 30 and 40 weeks equivalent gestational age in nine extremely preterm born infants.

Results

Using the resulting surface correspondence, we identified regions that undergo more cortical folding of the white-grey matter boundary during the

SUBMITTER: Orasanu E 

PROVIDER: S-EPMC4873564 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature