Placental Metal Concentrations in Relation to Maternal and Infant Toenails in a U.S. Cohort.

ABSTRACT: Metal contaminants cross the placenta, presenting a heightened risk of perturbing fetal development. Information about placental concentrations and transfer of multiple potentially toxic metals from low to moderate exposure is lacking. We measured concentrations of Cd, Pb, Hg, Mn, Se, and Zn in 750 placentas collected from women enrolled in the New Hampshire Birth Cohort Study and examined the correlation between elements, and profiles of potentially toxic metals (Cd, Pb, Hg, and Mn) stratified by nutrient concentrations (Zn and Se) using principal components analyses. We further examined the indirect effects of maternal metal concentrations on infant metal concentrations through placental metal concentrations using structural equation models. Placental metal concentrations were all correl

SUBMITTER: Punshon T 

PROVIDER: S-EPMC4873612 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature