Genetic loci associated with ideal cardiovascular health: A meta-analysis of genome-wide association studies.

ABSTRACT:

Background

Multiple genetic loci are associated with clinical cardiovascular (CV) disease and individual CV risk factors. Individuals with ideal levels of all major CV risk factors have very low risk for CV disease morbidity or mortality. Ideal levels of risk factors can be attained by lifestyle modifications; however, little is known about gene variants associated with ideal CV health. Our objective was to carry out a genome-wide association study on the trait.

Methods and results

We examined 2 dichotomous phenotypes of ideal CV health-clinical (untreated cholesterol <200 mg/dL, untreated blood pressure <120/<80, not diabetic) and clinical+behavioral (clinical plus: not a current smoker, body mass index <25 kg/m(2))-among white participants aged 50±5 years. We performed a m

SUBMITTER: Allen NB 

PROVIDER: S-EPMC4873714 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature