Possible mechanisms of host resistance to Haemonchus contortus infection in sheep breeds native to the Canary Islands.

ABSTRACT: Haemonchus contortus appears to be the most economically important helminth parasite for small ruminant production in many regions of the world. The two sheep breeds native to the Canary Islands display distinctly different resistant phenotypes under both natural and experimental infections. Canaria Hair Breed (CHB) tends to have significantly lower worm burden and delayed and reduced egg production than the susceptible Canaria Sheep (CS). To understand molecular mechanisms underlying host resistance, we compared the abomasal mucosal transcriptome of the two breeds in response to Haemonchus infection using RNAseq technology. The transcript abundance of 711 and 50 genes were significantly impacted by infection in CHB and CS, respectively (false discovery rate <0.05) while 27 of these genes

SUBMITTER: Guo Z 

PROVIDER: S-EPMC4873755 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature