Positive fertility outcomes in a female with classic congenital adrenal hyperplasia following bilateral adrenalectomy.

ABSTRACT:

Background

Classic congenital adrenal hyperplasia (CAH) requires lifetime steroid replacement and supraphysiologic glucocorticoid dose is often required for adequate adrenal androgen suppression. Patients often suffer from long-term co-morbidities and female infertility is common.

Case presentation

We report the use of laparoscopic bilateral adrenalectomy as a treatment for a 21 year old female with classic simple virilizing CAH and infertility. She presented as an adolescent with increasing weight gain, amenorrhea and elevated adrenal androgens despite the use of dexamethasone (250 mcg given twice daily), and fludrocortisone (150 mcg daily). An anti-androgen (flutamide 250 mg given twice daily) and a combined oral contraceptive pill were added to her regimen and prevented p

SUBMITTER: Dagalakis U 

PROVIDER: S-EPMC4873998 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature