Prospective study of bevacizumab plus temozolomide in patients with advanced neuroendocrine tumors.

ABSTRACT:

Purpose

Both tyrosine kinase inhibitors targeting the vascular endothelial growth factor (VEGF) receptor and bevacizumab, a monoclonal antibody targeting VEGF, have antitumor activity in neuroendocrine tumors (NETs). Temozolomide, an oral analog of dacarbazine, also has activity against NETs when administered alone or in combination with other agents. We performed a phase II study to evaluate the efficacy of temozolomide in combination with bevacizumab in patients with locally advanced or metastatic NETs.

Patients and methods

Thirty-four patients (56% with carcinoid, 44% with pancreatic NETs) were treated with temozolomide 150 mg/m(2) orally per day on days 1 through 7 and days 15 through 21, together with bevacizumab at a dose of 5 mg/kg per day intravenously on days 1 and

SUBMITTER: Chan JA 

PROVIDER: S-EPMC4874232 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature