Reproducibility and reliability of short-TE whole-brain MR spectroscopic imaging of human brain at 3T.

ABSTRACT:

Purpose

A feasibility study of an echo-planar spectroscopic imaging (EPSI) using a short echo time (TE) that trades off sensitivity, compared with other short-TE methods, to achieve whole brain coverage using inversion recovery and spatial oversampling to control lipid bleeding.

Methods

Twenty subjects were scanned to examine intersubject variance. One subject was scanned five times to examine intrasubject reproducibility. Data were analyzed to determine coefficients of variance (COV) and intraclass correlation coefficient (ICC) for N-acetylaspartate (NAA), total creatine (tCr), total choline (tCho), glutamine/glutamate (Glx), and myo-inositol (mI). Regional metabolite concentrations were derived by using multi-voxel analysis based on lobar-level anatomic regions.

Results

SUBMITTER: Ding XQ 

PROVIDER: S-EPMC4874643 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature