Effects of vitamin D supplementation during weight loss on sex hormones in postmenopausal women.

ABSTRACT:

Objective

The aim of the study was to compare the effects of vitamin D3 supplementation versus placebo on serum sex hormones in postmenopausal women completing a 12-month diet + exercise weight loss program.

Methods

Two hundred eighteen overweight or obese women (50-75 y) with serum 25-hydroxyvitamin D at least 10 to less than 32 ng/mL ("insufficient") were randomized to either weight loss + 2,000 IU/day oral vitamin D3, or to weight loss + daily placebo. Serum sex hormone-binding globulin, estrone, total, free, and bioavailable estradiol, and testosterone were measured by radioimmunoassay before randomization and at 12 months. Mean changes were compared between groups (intent-to-treat) using generalized estimating equations.

Results

The 12-month changes in sex hormon

SUBMITTER: Mason C 

PROVIDER: S-EPMC4874908 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature