Cell type specificity of signaling: view from membrane receptors distribution and their downstream transduction networks.

ABSTRACT: Studies on cell signaling pay more attention to spatial dynamics and how such diverse organization can relate to high order of cellular capabilities. To overview the specificity of cell signaling, we integrated human receptome data with proteome spatial expression profiles to systematically investigate the specificity of receptors and receptor-triggered transduction networks across 62 normal cell types and 14 cancer types. Six percent receptors showed cell-type-specific expression, and 4% signaling networks presented enriched cell-specific proteins induced by the receptors. We introduced a concept of "response context" to annotate the cell-type dependent signaling networks. We found that most cells respond similarly to the same stimulus, as the "response contexts" presented high functional

SUBMITTER: He Y 

PROVIDER: S-EPMC4875372 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature