Hepatitis E Virus Circulation in Italy: Phylogenetic and Evolutionary Analysis.

ABSTRACT:

Background

Hepatitis E virus (HEV), a major cause of acute viral hepatitis in developing countries, has been classified into four main genotypes and a number of subtypes. New genotypes have been recently identified in various mammals, including HEV genotype 3, which has a worldwide distribution. It is widespread among pigs in developed countries.

Objectives

This study investigated the genetic diversity of HEV among humans and swine in Italy. The date of origin and the demographic history of the HEV were also estimated.

Materials and methods

A total of 327 HEV sequences of swine and humans from Italy were downloaded from the national centre for biotechnology information. Three different data sets were constructed. The first and the second data set were used to confirm

SUBMITTER: Montesano C 

PROVIDER: S-EPMC4875568 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature